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Randy Goodall
Randy Goodall

Stingray 2008 Activation


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Stingray 2008 activation



Abstract:Animal venoms offer a valuable source of potent new drug leads, but their mechanisms of action are largely unknown. We therefore developed a novel network pharmacology approach based on multi-omics functional data integration to predict how stingray venom disrupts the physiological systems of target animals. We integrated 10 million transcripts from five stingray venom transcriptomes and 848,640 records from three high-content venom bioactivity datasets into a large functional data network. The network featured 216 signaling pathways, 29 of which were shared and targeted by 70 transcripts and 70 bioactivity hits. The network revealed clusters for single envenomation outcomes, such as pain, cardiotoxicity and hemorrhage. We carried out a detailed analysis of the pain cluster representing a primary envenomation symptom, revealing bibrotoxin and cholecystotoxin-like transcripts encoding pain-inducing candidate proteins in stingray venom. The cluster also suggested that such pain-inducing toxins primarily activate the inositol-3-phosphate receptor cascade, inducing intracellular calcium release. We also found strong evidence for synergistic activity among these candidates, with nerve growth factors cooperating with the most abundant translationally-controlled tumor proteins to activate pain signaling pathways. Our network pharmacology approach, here applied to stingray venom, can be used as a template for drug discovery in neglected venomous species.Keywords: transcriptomics; high-content screening; multi-omics data integration; drug discovery; venomics


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  • The C7 delivers astonishing acceleration, amazing grip, quick reflexes, and absolute communication through the seat and steering wheel. Even the automatic transmission matches the best of the German twin-clutch automatics. It comes as an awesome Stingray or mind-shattering Z06. The Stingray uses a 6.2-liter LT1 V8 making 455 horsepower and 460 pound-feet of torque. The Z06 uses a supercharged LT4 V8 that's also 6.2 liters, making 650 hp and 650 lb-ft. A 7-speed manual gearbox is standard, with automatic rev-matching downshifts. It's fantastic. The optional transmission is a GM-built paddle-shifting 8-speed automatic. It's superb. There's a model in the middle, the Grand Sport, which uses the Stingray engine and the Z06 suspension and steering geometry. It makes 5 more horsepower than the Stingray, and is a couple tenths quicker in the quarter mile. There's also a Z07 handling package that includes carbon-ceramic brakes. The Convertible doesn't lose any structural integrity, because the Corvette was designed from the ground up as a roadster; the Convertible isn't a coupe with the top chopped off afterward, it's a roadster with a top added. With a tall final-drive ratio keeping rpm low at freeway speed, and cylinder de-activation technology to cut cylinders when cruising, Corvette gets an EPA-rated 19 miles per gallon Combined. The Z06 rates 16 mpg Combined. Neither the NHTSA nor the IIHS have crash-tested the C7 Corvette, but its rigid structure, many airbags, and stability control inspire confidence. The best way to stay safe in a Corvette is don't lose your judgment. Full ReviewThe Chevrolet Corvette is in its seventh generation, or C7, and still comes across young and hot as ever. The 2018 Corvette is in the fifth year of this generation, having been introduced for 2014. There have been steady small changes in the past five model years, but nothing significant from a mechanical standpoint. It's so dynamically perfect that it hasn't needed changes to keep up with anyone. The C7 delivers astonishing acceleration, amazing grip, quick reflexes, and absolute communication through the seat and steering wheel. Even the automatic transmission matches the best of the German twin-clutch automatics. It comes as an awesome Stingray or mind-shattering Z06. The Stingray uses a 6.2-liter LT1 V8 making 455 horsepower and 460 pound-feet of torque. The Z06 uses a supercharged LT4 V8 that's also 6.2 liters, making 650 hp and 650 lb-ft. A 7-speed manual gearbox is standard, with automatic rev-matching downshifts. It's fantastic. The optional transmission is a GM-built paddle-shifting 8-speed automatic. It's superb. There's a model in the middle, the Grand Sport, which uses the Stingray engine and the Z06 suspension and steering geometry. It makes 5 more horsepower than the Stingray, and is a couple tenths quicker in the quarter mile. There's also a Z07 handling package that includes carbon-ceramic brakes. The Convertible doesn't lose any structural integrity, because the Corvette was designed from the ground up as a roadster; the Convertible isn't a coupe with the top chopped off afterward, it's a roadster with a top added. With a tall final-drive ratio keeping rpm low at freeway speed, and cylinder de-activation technology to cut cylinders when cruising, Corvette gets an EPA-rated 19 miles per gallon Combined. The Z06 rates 16 mpg Combined. Neither the NHTSA nor the IIHS have crash-tested the C7 Corvette, but its rigid structure, many airbags, and stability control inspire confidence. The best way to stay safe in a Corvette is don't lose your judgment. Hide Full ReviewChoose a Trim2dr Coupe (Stingray)2dr Convertible (Stingray)2dr Coupe (Stingray Z51)2dr Convertible (Stingray Z51)2dr Coupe (Grand Sport)2dr Convertible (Grand Sport)2dr Coupe (Z06)2dr Convertible (Z06)Retail Price$64,495MSRP / Window Sticker PriceFind Best PriceEngine6.2L V-8MPG16 City / 25 HwySeating2 PassengersTransmission7-spd man w/ODPower460 @ 6000 rpmDrivetrainrear-wheelSmart Buy Program is powered by Latest Corvette NewsHennessey 'H700' C8 Corvette revealed, cranked to 708 supercharged horsepower

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